Members of the RHU SHIVA project have participated to the 29th Organization for Human Brain Mapping Annual meeting 2023 (OHBM2023).
Dr. Ami Tsuchida, SHIVA researcher in the GIN neuroimaging group, participated to the OHBM 2023 with a poster on the characterization of neuroimaging markers of covert cerebral small vessel disease in the MRi-Share study.
–> Description 2 prominent markers of cerebral small vessel disease in a large cohort of young adults from the MRi-Share (N = 1,831, aged 18-35 years): white matter hyperintensities and perivascular spaces
–> Higher amounts of white matter hyperintensities and perivascular spaces are associated with an inscrease of peak width of skeletonized mean diffusivity (PSMD) and a decrease of neurite density index (NDI)
–> Even the small amounts of visible cSVD markers are already associated with signs of compromised white matter integrity in young, neurologically asymptomatic adults.
Dr Frauke Beyer, post-doctorant fellow in the SHIVA consortium, contributed to this OHBM Annual meeting with a poster on the spatial patterns of white matter hyperintensities (WMH) and their link to cardiovascular risk and cognition in two cohorts: the French 3 City study and the German LIFE-Adult study.
–> These results show that frontal-periventricular WMH are more related to hypertension while deep WMH in temporal, occipital and parietal lobe are related to obesity. This could help to identify different mechanisms at play during the development of the white matter hyperintensities.
–> Spatial patterns reflect known associations of WMH with risk factors and cognitive outcomes but also uncover specific effects, possibly related to different etiologies.
