The SHIVA research program aims at developing personalized management of cerebral Small Vessel Desease (cSVD) : a new paradigm for preventing stroke, cognitive decline & dementia.
Small vessels disease (SVD) is an age-related disease that results from alterations in the structure and/or function of the small arteries that supply blood to the brain. It is one of the main causes of stroke, memory loss and dementia in the elderly. The brain lesions that characterize it, and which are secondary to the damage of these small arteries, can be of several types: white matter hyperintensities (localized alteration of the white matter of the brain), brain lacunae (appearance of small cavities resulting from the destruction of the cerebral tissue), microbleeds (small bleedings occurring in the brain) or dilatation of the perivascular spaces (widening of the spaces surrounding the small blood vessels of the brain).
SVD is most often "covert" (cSVD), i.e. detectable only on a brain Magnetic Resonance Imaging.
Major role of cerebrovascular disease in pathophysiology of dementia :
A major target for healthy brain aging !
- Covert Cerebral Small Vessel Disease :
The most frequent substrate of the vascular contribution to cognitive decline and dementia.
- Very common in older persons :
More than 4 million people over 60 in France affected by cSVD.
- Strongly associated with risk of stroke, cognitive decline & dementia.
- No specific mechanistic treatment to date.
- No recommendations on prevention.
The project is organized around 6 Workpackages (WP) with strong interactions covering :
The proposed WP leaderships reflect a combination of high level methodological expertise, and strong clinical expertise and involvement to ensure optimal recruitment for the SHIVA cohort and rapid implementation of SHIVA results for improved patient care.
The SHIVA project is supported by the University of Bordeaux and coordinated by Pr Stephanie Debette (coordinator) and Pr Thierry Couffinhal (co-coordinator).
The SHIVA's Governance ensure that the objectives, timeline and finances of the project are respected in the interest of the consortium, but also the scientific and ethical coherence of the project. The Governance is constituted by the Coordinating Institution, the General Assembly and the Executive Committee with the support of operational and consultative bodies.
- GENERAL ASSEMBLY (GA)
- SHIVA PROJECT COORDINATION TEAM (PCT)
- EXECUTIVE COMMITTEE (ExC)
- SCIENTIFIC ADVISORY BOARD (SAB)
- ETHICS ADVISORY BOARD (EAB)
- BUSINESS LIAISON COMMITTEE (BLC)
The team is specifically assigned to monitoring the project and is involved in the organisational, scientific and technical aspects in close collaboration with the partnership and development support provided by the Université de Bordeaux.
PROJECT COORDINATION TEAM
The team is specifically assigned to monitoring the project and is involved in the organisational, scientific and technical aspects in close collaboration with the partnership and development support provided by the University of Bordeaux.
SHIVA Coordinator, WP6 Leader, Neurologist
SHIVA Co-coordinator, WP3 Leader, Cardiologist
Judith THOMAS CRUSELLS
Clinical project manager
Administrative & financial manager