👏 Congratulations to all SHIVA researchers and members of the VBHI Institute on the publication of their article in Communications Biology: “Endothelial TRIM47 regulates blood–brain barrier integrity and cognition via the KEAP1/NRF2 signaling pathway in mice.”
This work, carried out within INSERM Unit 1034, University of Bordeaux – Biology of Cardiovascular Diseases (Claire PEGHAIRE, Thierry COUFFINHAL, Cécile DUPLAA, Valentin DELOBEL, Camille GRENIER), was supported by RHU SHIVA and VBHI, and involved collaborations with U1219-BPH (Stéphanie DEBETTE, Ilano CARO, Aniket MISHRA) and INCIA UMR5287 (Bruno BONTEMPI, Jean-Luc MOREL).
🔬 Key findings:
• TRIM47 is a key regulator of blood–brain barrier integrity
• Endothelial loss of TRIM47 contributes to vascular dementia
• Targeting the TRIM47/NRF2 antioxidant pathway represents a promising therapeutic strategy
Open access article at: https://www.nature.com/articles/s42003-026-09628-5