Quentin Le Grand, Ami Tsuchida, Alexandra Koch, Mohammed-Aslam Imtiaz, N. Ahmad Aziz, Chloé Vigneron, Laure Zago, Mark Lathrop, Alexandre Dubrac, Thierry Couffinhal, Fabrice Crivello, Paul M. Matthews, Aniket Mishra, Monique M. B. Breteler, Christophe Tzourio & Stéphanie Debette. Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease. Mol Psychiatry 29, 3567–3579 (2024). https://doi.org/10.1038/s41380-024-02604-7.
We are pleased to present our new collaborative publication between the University of Bordeaux and the German Center for Neurodegenerative Diseases, published in Molecular Psychiatry and authored by Quentin Le Grand and RHU SHIVA researchers:
“Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease”.
➡ Using an association approach between advanced diffusion imaging markers, scatter imaging and neurite density imaging in subjects of different ages, this study was able to demonstrate the possible existence of early mechanisms underlying Creutzfeldt-Jakob disease and processes involving remyelination, neurodevelopment and neurodegeneration, with the potential for new approaches to prevention.
These mechanisms were highlighted by the identification of several new genetic loci associated with NODDI markers in young adults (i-Share study), with follow-up in middle-aged people (Rhineland study) and in middle-aged to elderly people (UK Biobank).
The article is available here.
