Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, Gudjonsson A, Mishra A, Bouteloup V, Phuah CL, van Duijn CM, Cruchaga C, Dufouil C, Chêne G, Lopez OL, Psaty BM, Tzourio C, Amouyel P, Adams HH, Jacqmin-Gadda H, Ikram MA, Gudnason V, Milani L, Winsvold BS, Hveem K, Matthews PM, Longstreth WT, Seshadri S, Launer LJ, Debette S. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia. JAMA Netw Open. 2024 May 1;7(5):e2412824. doi: 10.1001/jamanetworkopen.2024.12824. PMID: 38776079; PMCID: PMC11112447.
Very excited to share the new collaborative publication in JAMA Network Open led by Dr. Muralidharan Sargurupremraj and involving RHU SHIVA researchers: « Cerebral Small Vessel Disease, Blood Pressure, and Dementia« .
➡ Using mendelian randomization, this study showed:
– a putative causal association of larger white matter hyperintensity (WMH) burden with increased Alzheimer disease risk after accounting for pulse pressure effects,
– an association of lower blood pressure with Alzheimer disease risk with possible confounding by shared genetic instruments.
📈 Longitudinal analyses on individual-level data supported the association of genetically determined larger WMH with incident all-cause dementia and Alzheimer disease, independently of interim stroke.
💡 These findings suggest that white matter hyperintensity is a primary vascular factor associated with dementia risk, emphasizing its significance in preventive strategies for dementia. Future studies are warranted to examine whether this finding can be generalized to non-European populations.
The article here.
