{"id":1914,"date":"2026-02-25T15:33:25","date_gmt":"2026-02-25T14:33:25","guid":{"rendered":"https:\/\/rhu-shiva.com\/fr\/?p=1914"},"modified":"2026-02-25T15:33:25","modified_gmt":"2026-02-25T14:33:25","slug":"endothelial-trim47-regule-lintegrite-de-la-barriere-hemato-encephalique-et-la-cognition-via-la-voie-de-signalisation-keap1-nrf2-chez-la-souris","status":"publish","type":"post","link":"https:\/\/rhu-shiva.com\/fr\/blog\/2026\/02\/25\/endothelial-trim47-regule-lintegrite-de-la-barriere-hemato-encephalique-et-la-cognition-via-la-voie-de-signalisation-keap1-nrf2-chez-la-souris\/","title":{"rendered":"Endothelial TRIM47 r\u00e9gule l\u2019int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique et la cognition via la voie de signalisation KEAP1\/NRF2 chez la souris"},"content":{"rendered":"\n<p>\ud83d\udc4f F\u00e9licitations \u00e0 l\u2019ensemble des chercheurs SHIVA and membres de l\u2019institut VBHI, pour la publication de leur article sur Communications Biology : \u00ab Endothelial TRIM47 r\u00e9gule l\u2019int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique et la cognition via la voie de signalisation KEAP1\/NRF2 chez la souris \u00bb.<\/p>\n\n\n\n<p>Ce travail, r\u00e9alis\u00e9 au sein de l\u2019Unit\u00e9 INSERM 1034, Universit\u00e9 de Bordeaux \u2013 Biologie des Maladies Cardiovasculaires (Claire PEGHAIRE, Thierry COUFFINHAL, C\u00e9cile DUPLAA, Valentin DELOBEL, Camille GRENIER), a \u00e9t\u00e9 soutenu par le RHU SHIVA et le VBHI, et a impliqu\u00e9 des collaborations avec l\u2019U1219-BPH (St\u00e9phanie DEBETTE, Ilano CARO, Aniket MISHRA) ainsi qu\u2019avec l\u2019INCIA UMR5287 (Bruno BONTEMPI, Jean-Luc MOREL).<\/p>\n\n\n\n<p>\ud83d\udd2c <strong>Principaux r\u00e9sultats :<\/strong><br>\u2022 TRIM47 est un r\u00e9gulateur cl\u00e9 de l\u2019int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique<br>\u2022 La perte endoth\u00e9liale de TRIM47 contribue \u00e0 la d\u00e9mence vasculaire<br>\u2022 Cibler la voie antioxydante TRIM47\/NRF2 repr\u00e9sente une strat\u00e9gie th\u00e9rapeutique prometteus<\/p>\n\n\n\n<p>Article en access libre: <a href=\"https:\/\/www.nature.com\/articles\/s42003-026-09628-5\">https:\/\/www.nature.com\/articles\/s42003-026-09628-5<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83d\udc4f F\u00e9licitations \u00e0 l\u2019ensemble des chercheurs SHIVA and membres de l\u2019institut VBHI, pour la publication de leur article sur Communications Biology : \u00ab Endothelial TRIM47 r\u00e9gule<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[6,2],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Endothelial TRIM47 r\u00e9gule 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