{"id":1887,"date":"2025-11-25T12:03:17","date_gmt":"2025-11-25T11:03:17","guid":{"rendered":"https:\/\/rhu-shiva.com\/fr\/?p=1887"},"modified":"2025-11-27T13:39:50","modified_gmt":"2025-11-27T12:39:50","slug":"une-nouvelle-signature-biologique-de-la-maladie-des-petits-vaisseaux-cerebraux","status":"publish","type":"post","link":"https:\/\/rhu-shiva.com\/fr\/blog\/2025\/11\/25\/une-nouvelle-signature-biologique-de-la-maladie-des-petits-vaisseaux-cerebraux\/","title":{"rendered":"Une nouvelle signature biologique de la maladie des petits vaisseaux c\u00e9r\u00e9braux"},"content":{"rendered":"\n

La maladie des petits vaisseaux du cerveau (MPVC) est l\u2019une des principales causes d\u2019Accident Vasculaire C\u00e9r\u00e9bral (AVC) et de d\u00e9mence, mais nous ne comprenons encore que partiellement ses m\u00e9canismes et il n\u2019existe pas de traitement sp\u00e9cifique. Pour mieux l\u2019\u00e9tudier, le Dr Ilana Caro, le Pr St\u00e9phanie Debette et leurs collaborateurs ont analys\u00e9 plus de 2 500 prot\u00e9ines<\/strong> pr\u00e9sentes dans des \u00e9chantillons sanguins et de liquide c\u00e9phalo-rachidien<\/strong>, qui ont \u00e9t\u00e9 recueillis chez des participants de plusieurs \u00e9tudes cliniques (l’\u00e9tude 3C<\/a> notamment). Ils ont compar\u00e9 ces donn\u00e9es avec les images c\u00e9r\u00e9brales (IRM) provenant de plus de 40 000 personnes<\/strong>.<\/p>\n\n\n\n

Ces travaux ont permis d’identifier 49 prot\u00e9ines li\u00e9es \u00e0 des signes visibles de la maladie sur l\u2019IRM<\/strong>, surtout dans le liquide c\u00e9phalo-rachidien. Ces prot\u00e9ines semblent impliqu\u00e9es dans des ph\u00e9nom\u00e8nes biologiques cl\u00e9s comme la r\u00e9action immunitaire, l\u2019activit\u00e9 de cellules de d\u00e9fense du cerveau et la structure qui soutient les tissus.<\/p>\n\n\n\n

Plusieurs de ces prot\u00e9ines sont aussi associ\u00e9es \u00e0 l\u2019AVC et \u00e0 la d\u00e9mence et correspondent \u00e0 des cibles de m\u00e9dicaments qui sont d\u00e9j\u00e0 disponibles. Cela ouvre la voie \u00e0 la d\u00e9couverte de nouveaux biomarqueurs<\/strong> de la maladie des petits vaisseaux c\u00e9r\u00e9braux et peut-\u00eatre \u00e0 la reposition des traitements<\/strong> existants pour mieux pr\u00e9venir ou soigner la maladie.<\/p>\n\n\n\n

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Lire l’article complet dans le journal Nature Aging<\/em><\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

La maladie des petits vaisseaux du cerveau (MPVC) est l\u2019une des principales causes d\u2019Accident Vasculaire C\u00e9r\u00e9bral (AVC) et de d\u00e9mence, mais nous ne comprenons encore que [\u2026]<\/span><\/p>\n","protected":false},"author":4,"featured_media":1899,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[6,2],"tags":[],"yoast_head":"\nUne nouvelle signature biologique de la maladie des petits vaisseaux c\u00e9r\u00e9braux | RHU SHIVA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rhu-shiva.com\/fr\/blog\/2025\/11\/25\/une-nouvelle-signature-biologique-de-la-maladie-des-petits-vaisseaux-cerebraux\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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