{"id":1775,"date":"2025-04-24T17:22:24","date_gmt":"2025-04-24T15:22:24","guid":{"rendered":"https:\/\/rhu-shiva.com\/fr\/?p=1775"},"modified":"2025-04-24T17:22:39","modified_gmt":"2025-04-24T15:22:39","slug":"des-lesions-inapercues-dans-le-cerveau-ralentissent-la-pensee","status":"publish","type":"post","link":"https:\/\/rhu-shiva.com\/fr\/blog\/2025\/04\/24\/des-lesions-inapercues-dans-le-cerveau-ralentissent-la-pensee\/","title":{"rendered":"Des l\u00e9sions inaper\u00e7ues dans le cerveau ralentissent la pens\u00e9e"},"content":{"rendered":"\n

Avec la maladie d’Alzheimer, les alt\u00e9rations du syst\u00e8me vasculaire du cerveau sont la cause la plus fr\u00e9quente de d\u00e9mence.<\/p>\n\n\n\n

Les l\u00e9sions de la substance blanche du cerveau<\/strong> sont des signes de minuscules l\u00e9sions vasculaires dans le cerveau et peuvent \u00eatre mesur\u00e9es par IRM c\u00e9r\u00e9brale. Elles sont tr\u00e8s fr\u00e9quentes chez les personnes \u00e2g\u00e9es et sont li\u00e9es, par exemple, \u00e0 un ralentissement des capacit\u00e9s de r\u00e9flexion dans la vie quotidienne.<\/p>\n\n\n\n

\u00c0 l’aide des donn\u00e9es de plus de 2 800 participants \u00e0 l’\u00e9tude \u00e2g\u00e9s de plus de 65 ans (issues de la cohorte fran\u00e7aise 3C<\/a> et de l’\u00e9tude allemande LIFE-Adulte) , les membres du consortium du RHU SHIVA, le Dr Frauke Beyer et Pr Debette St\u00e9phanie ont cherch\u00e9 \u00e0 savoir o\u00f9 ces l\u00e9sions se produisent dans le cerveau, quels facteurs favorisent leur apparition et comment elles sont li\u00e9es aux accidents vasculaires c\u00e9r\u00e9braux et \u00e0 la d\u00e9mence.<\/p>\n\n\n\n

\n

\u00ab Il n’existe actuellement aucun traitement pour ces l\u00e9sions, alors qu’elles constituent un facteur de risque majeur d’accident vasculaire c\u00e9r\u00e9bral et de d\u00e9mence \u00bb<\/p>\nFrauke Beyer, auteur principal de l’\u00e9tude, r\u00e9cemment publi\u00e9e dans la revue Alzheimer’s and Dementia<\/em>.<\/cite><\/blockquote>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

Pour savoir comment les m\u00e9dicaments existants pourraient \u00eatre prescrits, il \u00e9tait important pour les chercheurs de comprendre d’abord quels facteurs jouent un r\u00f4le dans le d\u00e9veloppement des l\u00e9sions \u00e0 diff\u00e9rents endroits du cerveau. Pour ce faire, ils ont analys\u00e9 l’ADN et les \u00e9chantillons de sang des participants \u00e0 l’\u00e9tude, originaires d’Allemagne et de France, qui devaient \u00e9galement r\u00e9soudre des t\u00e2ches mentales tout en \u00e9tant allong\u00e9s dans un scanner d’imagerie par r\u00e9sonance magn\u00e9tique (IRM).<\/p>\n\n\n\n

\n

\u00ab\u00a0Nous avons constat\u00e9 que les l\u00e9sions se produisent \u00e0 des endroits typiques du cerveau, probablement parce qu’elles sont bas\u00e9es sur des m\u00e9canismes diff\u00e9rents. Dans le cas des l\u00e9sions autour des ventricules, c’est surtout l’hypertension art\u00e9rielle qui joue un r\u00f4le, et dans le cas des l\u00e9sions dans la substance blanche profonde, nous soup\u00e7onnons un lien avec le d\u00e9p\u00f4t d’amylo\u00efde dans les parois des vaisseaux, une prot\u00e9ine que l’on retrouve \u00e9galement dans la maladie d’Alzheimer. Ces l\u00e9sions pouvant \u00eatre visibles d\u00e8s l’\u00e2ge de quarante ans, on pourrait faire plus en mati\u00e8re de pr\u00e9vention dans ce domaine\u00a0\u00bb<\/p>\nFrauke Beyer<\/cite><\/blockquote>\n\n\n\n

L’hypertension art\u00e9rielle est le facteur de risque le plus constant et de loin le plus important pour le d\u00e9veloppement des l\u00e9sions que nous ayons d\u00e9couvert, tout comme un IMC plus \u00e9lev\u00e9.<\/strong> Ce qui est d\u00e9licat, c’est que les l\u00e9sions du syst\u00e8me vasculaire sont un processus graduel – le cerveau des personnes touch\u00e9es traite souvent les informations plus lentement que la normale dans la vie de tous les jours, mais autrement, elles ne le remarquent souvent pas.\u00a0\u00bb<\/p>\n\n\n\n

Les scientifiques souhaitent maintenant mener des \u00e9tudes de suivi pour d\u00e9couvrir quels facteurs g\u00e9n\u00e9tiques pourraient \u00eatre \u00e0 l’origine des l\u00e9sions aux diff\u00e9rents endroits du cerveau. Cela pourrait permettre de mettre au point des th\u00e9rapies cibl\u00e9es \u00e0 l’avenir.<\/p>\n\n\n\n

\n
Lire la publication scientifique dans Alzheimer’s and Dementia<\/a><\/div>\n\n\n\n
Communiqu\u00e9 de presse Allemand<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Avec la maladie d’Alzheimer, les alt\u00e9rations du syst\u00e8me vasculaire du cerveau sont la cause la plus fr\u00e9quente de d\u00e9mence. 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